Composition
Main ingredients:lidocaine hydrochloride.
Chemical name: N- (dichloroxylyl) -2- (diethylamino) acetamide hydrochloride monohydrate
The molecular formula: c14h22n2o HCI h20
Molecular weight: 288.82
Character
This product is colorless and clear liquid.
Indication
This product is a local anesthetic and antiarrhythmic. It is mainly used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including mucosal anesthesia during thoracoscopy or abdominal surgery) and nerve conduction block. This product can be used for ventricular premature beat and ventricular tachycardia after acute myocardial infarction, and can also be used for digitalis poisoning, cardiac surgery and ventricular arrhythmia caused by cardiac catheter. This product is usually ineffective for supraventricular arrhythmia.
adverse effect
(1) This product can act on the central nervous system, causing drowsiness, paresthesia, muscle tremor, convulsion coma, respiratory depression and other adverse reactions.
(2) It can cause hypotension and bradycardia. Excessive blood concentration can cause atrial conduction velocity to slow down, atrioventricular block, inhibit myocardial contractility and decrease cardiac output.
As a generic drug supplier in China, Feiyue Pharmaceutical can provide finished drugs such as Lidocaine Hydrochloride InjECTion
Packaging: 10ml：0.1g
FEIYUE recruits agents worldwide, we can provide complete registration documents.
Taboo
- (1) those who are allergic to local anesthetics are forbidden;
- (2) Vein is forbidden for patients with Arjen-Stokes syndrome (acute cardiogenic cerebral ischemia syndrome), preexcitation syndrome and severe heart block (including sinus block, atrioventricular block and intraventricular block).
Matters need attention
- (1) Non-intravenous drug administration should prevent it from straying into blood vessels, and pay attention to the diagnosis and treatment of local anesthetic poisoning symptoms.
- (2) During medication, attention should be paid to checking blood pressure, monitoring electrocardiogram, and providing rescue equipment; If the P-R interval of ECG is prolonged or QRS wave is widened, and other arrhythmia or the original arrhythmia is aggravated, the drug should be stopped immediately.
Drug interaction
- (1) When used in combination with cimetidine and beta blockers, such as propranolol, metoprolol and nadolol, the metabolism of lidocaine in the liver is inhibited, and the blood concentration of lidocaine increases, which may lead to adverse reactions in the heart and nervous system. The dosage of lidocaine should be adjusted, and the blood concentration of lidocaine should be monitored and monitored by electrocardiogram.
- (2) It has incompatibility with the following drugs: amphotericin B, ampicillin, mezobitol and sulfadiazine.
Pharmacology
This product is an amide local anesthetic. After blood absorption or intravenous administration, it has obvious biphasic effects of excitation and inhibition on central nervous system, and there is no precursor excitation. When the blood concentration is low, there will be analgesia, sleepiness and pain threshold increase. With the increase of dose, the effect or toxicity is enhanced, and the sub-toxic blood concentration has anticonvulsant effect; Convulsions can occur when the blood drug concentration exceeds 5ug/ml. At low dose, this product can promote the outflow of K+ in myocardial cells, reduce the self-discipline of myocardium, and have the effect of resisting ventricular arrhythmia. At the treatment dose, there was no obvious effect on the electrical activity of myocardial cells, atrioventricular conduction and myocardial contraction. The further increase of blood concentration can cause heart conduction velocity to slow down, atrioventricular block, inhibit myocardial contractility and decrease cardiac output.
Pharmacokinetics
After injection, the tissue is distributed quickly and widely, and it can penetrate the blood-brain barrier and placenta. This product has strong anesthetic intensity, quick effect and strong dispersing power. It takes about 2 hours for the drug to be eliminated locally, and the action time can be prolonged by adding epinephrine. Most of them were degraded by liver microsomal enzyme to monoethyl glycinamide xylene, which still had local anesthetic effect. The toxicity increased, and then they were hydrolyzed by amidase and excreted in urine. About 10% of the dosage was excreted in the original form, and a small amount appeared in bile.
Store up
Sealed storage.